Effects of nitric oxide inhibitors in mice with bladder outlet obstruction

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Effects of nitric oxide inhibitors in mice with bladder outlet obstruction

PURPOSE To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), after 5 weeks of partial bladder outlet obstruction (BOO), in order to evaluate the role of constitutive and non-constitutive NOS in the pathogenesis of this...

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L-NAME, a nitric oxide synthase inhibitor, diminishes oxidative damage in urinary bladder partial outlet obstruction.

Partial bladder outlet obstruction (PBOO) results in cellular damage due to ischemia and reperfusion injury. Our study seeks to establish how early this damage can occur and the role that nitric oxide may play in its pathophysiology. Surgical PBOO (1, 3, and 7 days) were performed on male New Zealand White rabbits. Half of the animals were premedicated for 3 days with N(G)-nitro-l-arginine meth...

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Temporary atrial standstill in a crossbred dog associated with bladder outlet obstruction

A 6-year-old male crossbred dog was referred to the Veterinary Medical Teaching Hospital of Islamic Azad University of Karaj with the history of abdominal distention, rectal tenesmus and stranguria. Abdominal radiographs and ultrasonography indicated large distended urinary bladder and prostatic enlargement. ECG showed temporary episodes of atrial standstill. The only abnormalities detected by ...

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Effects of tamsulosin on bladder blood flow and bladder function in rats with bladder outlet obstruction.

OBJECTIVES To investigate the mechanism underlying the ameliorating effect of tamsulosin, an alpha(1)-adrenoceptor antagonist, on storage symptoms associated with benign prostatic hyperplasia, the effects of tamsulosin on bladder blood flow (BBF) and bladder function was evaluated in rats with bladder outlet obstruction (BOO). METHODS BOO was produced by partial ligature of the proximal ureth...

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EXPERIENCE WITH BLADDER NECK INCISION TO RELIEVE BLADDER OUTLET OBSTRUCTION VERSUS TRANSURETHRAL RESECTION OF THE PROSTATE IN SHIRAZ

TUR is cited as the treatment of choice for relief of bladder outflow tract obstruction in the male, but bladder neck incision (BNI) is an acceptable alternative when the gland is smalI.1,2,3 Sixty cases of BNIfTUR have been reviewed (BNI=35, TUR=25) from March, 1986 to April, 1988. BNI was done when the glands were less than 30 gr , and when there was no clinical suspicion of malignancy t...

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ژورنال

عنوان ژورنال: International braz j urol

سال: 2017

ISSN: 1677-5538

DOI: 10.1590/s1677-5538.ibju.2015.0441